Mammary Effects from Atrazine Metabolite Mixture

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Omschrijving
Atrazine, a widely used chlorotriazine herbicide, inhibits a number of endocrine-dependent processes, including gonadotrophin surges and mammary gland development in rats. Because chlorotriazine herbicide metabolites are present both in the environment and in exposed animals, Enoch et al. (p. 541) investigated whether a mixture of atrazine metabolites might produce developmental effects in rats after exposure in late pregnancy. The data suggest that acute exposure at levels as low as 0.09 mg/kg body weight during late pregnancy causes persistent alterations in mammary gland development of female offspring, and that these effects do not appear to be related to body weight or associated with pubertal timing.

 

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Categorie: pesticiden

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