Strain Differences and the Response to Estrogens
Omschrijving
Studies of low-dose effects of xenoestrogens have yielded conflicting results that may be attributed to differences in estrogen sensitivity between rodent strains. Perinatal exposure of CD-1 mice to low doses of the xenoestrogen bisphenol A (BPA) alters peripubertal mammary gland development. Future studies of BPA action require estrogen receptor knock-out mice that were generated on a C57Bl6 background. Wadia et al. (p. 592) examined whether the mammary glands of CD-1 and C57Bl6 mice exhibited similar responses to 17?-estradiol (E2) and whether perinatal exposure to BPA equally enhanced sensitivity of the mammary glands to E2 at puberty.
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