Genetic Polymorphisms Influencing Arsenic Metabolism

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Omschrijving
The susceptibility to arsenic-induced diseases differs greatly between individuals, possibly because of interindividual variations in arsenic metabolism affecting retention and distribution of toxic metabolites. To elucidate the role of genetic factors in arsenic metabolism, Schläwicke Engström et al. (p. 599) studied how polymorphisms in six genes affected the urinary metabolite pattern in a group of indigenous women in northern Argentina who were exposed to approximately 200 µg/L arsenic in drinking water. The findings indicate that polymorphisms in arsenic(+III)methyltransferase (AS3MT), and possibly glutathione S-transferases mu 1 (GSTM1) and theta (GSTT1), 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), and methylenetetrahydrofolate reductase (MTHFR) are responsible for a large part of the interindividual variation in arsenic metabolism and susceptibility.

 

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