Dose Response for Mercury and IQ
Omschrijving
Prenatal exposure to mercury has been associated with adverse childhood neurologic outcomes in epidemiologic studies; dose–response information for this relationship is useful for estimating benefits of reduced mercury exposure. Axelrad et al. (p. 609) estimated a dose–response relationship between maternal mercury body burden and subsequent childhood decrements in intelligence quotient (IQ). IQ is a useful end point for estimating neurodevelopmental effects, but it may not fully represent cognitive deficits associated with mercury exposure and it does not represent deficits related to attention and motor skills. Nevertheless, the integrated IQ coefficient provides a more robust description of the dose–response relationship for prenatal mercury exposure and cognitive functioning.
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