Parental Smoking, TNF, and Asthma

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Omschrijving
Polymorphisms in the proinflammatory cytokine genes tumor necrosis factor-? (TNF) and lymphotoxin-? (LTA, also called TNF-?) have been associated with asthma and atopy in some studies. Parental smoking is a consistent risk factor for childhood asthma. Secondhand smoke and ozone both stimulate TNF production. Wu et al. (p. 616) investigated whether genetic variations in TNF and LTA are associated with asthma and atopy and whether the association is modified by parental smoking in a Mexican population with high ozone exposure. The results suggest that genetic variation in TNF may contribute to childhood asthma and that associations may be modified by parental smoking.

 

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Categorie: roken - astma

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