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UCLA Study Challenges Conventional Treatment After Traumatic Brain Injury


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The chemical lactate has gotten a bad rap. Conventional wisdom considered it to be little more than the bane of runners and other athletes, causing stiff muscles and fatigue, and the "sour" in sour milk. It turns out that view may have been too narrow. Neuroscientists at UCLA are now looking at lactate with a much more positive eye, considering it a possible replacement "fuel" for the brain in the immediate hours after a traumatic brain injury instead of glucose, the current standard. If they are right, it could change how emergency room physicians and intensive care physicians treat patients with brain injuries in the first critical hours after injury. Previous work by Dr. Neil Martin, professor and chief of neurosurgery at the David Geffen School of Medicine at UCLA, and Thomas Glenn, a UCLA adjunct assistant professor in the department of neurosurgery, showed that the brain takes up lactate after traumatic injury. Now, thanks to a $275,000 grant from the National Institute for Neurological Diseases and Stroke at the National Institutes of Health, the investigators will determine why the brain does this. Is it actually using lactate to help it recover after injury?

 

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