Fetal alcohol research

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Omschrijving
In the lab, Smith focuses on a small sub-population of fetal cells called neural crest cells that contribute to the formation of parts of the nervous system, face and heart. These cells are damaged and sometimes killed by alcohol, and children with fetal alcohol exposure can suffer damage to those organs, including visible facial malformations. Studying the effect of alcohol on chicken embryos, Smith was able to show that alcohol somehow directs the neural crest cells to end their own lives. "Cell death is an active process," explains Smith. "A cellular switch has to be turned on for cell death to occur. Usually the switch is suppressed, or kept silent. Alcohol is toxic because it can turn that switch on, and it does so by causing cells to release calcium."

 

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Categorie: alcohol - baby

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