Mechanistic Link Discovered between Calcium Signaling and Alzheimer Gene

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Omschrijving
Scientists from the Institute for Aging and Alzheimer’s Disease Research (IAADR) based in Fort Worth, Texas, have discovered a molecular mechanism that links the activity of a crucial protein involved in Alzheimer’s disease with a fundamental signaling process in nerve cells. Published online in The International Journal of Biochemistry & Cell Biology , the research was funded by the National Institute on Aging (NIA), part of the National Institutes of Health (NIH) and the Alzheimer’s Association. The discovery builds on previous research from several NIA-funded laboratories that identified mutations in the Alzheimer’s disease related gene presenilin-1 as the cause of impaired activity and reduced health of nerve cell in the brain. The study’s lead investigator, Peter Koulen, Ph.D., of the IAADR at the University of North Texas Health Science Center had two major goals when he initiated the study in 2003: to identify the role of normal, so-called wild-type presenilin-1 in regulating neuronal function, and to reach the mechanism that drives this function. This appeared to be of particular relevance because only a small portion of Alzheimer’s disease sufferers carries such mutations (often called familial Alzheimer’s disease), while the majority of patients have sporadic Alzheimer’s disease, in which no apparent direct genetic changes have been identified.

 

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Categorie: alzheimer

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