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NIH scientists discover novel cause of iron overload in thalassemia disorders

Researchers at NIH have discovered a novel cause of iron overload in patients with thalassemia. According to the study, thalassemia patients overproduce a protein called GDF15, which suppresses the production of a liver protein, hepcidin, which in turn leads to an increase in the uptake of dietary iron in the gut. This finding has implications for iron metabolism in other diseases and may contribute to the future development of therapies for thalassemia.


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Categorie: ijzer


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