New Research May Predict Who is at Risk to Develop Lupus

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Omschrijving
Certain families produce higher levels of a specific molecule, called interferon-alpha, that primes the body’s immune system to turn on, and in some cases initiate an autoimmune attack on itself, according to new research from Hospital for Special Surgery in New York City. Our immune system is able to defeat disease-causing viruses and bacteria every day using chemical weapons, like interferon-alpha, that have been honed over time. But like anything else, we can have too much of a good thing. Using blood samples from two large repositories, rheumatologist Mary K. Crow, M.D., and her colleagues at Hospital for Special Surgery compared 266 patients with systemic lupus erythematosus (SLE), an autoimmune disease, with 405 of their healthy relatives. Specifically, Dr. Crow, who is director of Rheumatology Research and associate chief of the Division of Rheumatology at Hospital for Special Surgery, and her team were looking at levels of interferon-alpha. The researchers found that when an SLE patient had high blood levels, so did many of their healthy first degree family members. There was a genetic link.

 

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Categorie: lupus

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