Low-carb diets' effects linked to rise in newly identified 'starvation hormone'

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Omschrijving
The benefits sometimes seen in those on a low-carbohydrate, high-fat diet may depend on increased levels of a newly identified "starvation hormone" produced by the liver, according to a report in the June issue of the journal Cell Metabolism, published by Cell Press. Two studies in the issue show that the hormone plays a critical role in the metabolic shift seen in animals after a period of fasting and in those fed an Atkins-like diet. That shift is characterized by an increased reliance on fat stores as an alternative source of fuel when glucose, the body’s primary energy source, plummets. A team led by Eleftheria Maratos-Flier of Harvard University reports evidence that increased blood levels of liver-derived "fibroblast growth factor 21" (FGF21) are required for fasted mice and mice on a carbohydrate-restricted diet to switch gears and begin burning fat. Likewise, an accompanying study led by Steven Kliewer of the University of Texas Southwestern Medical Center found that FGF21 mobilizes fat in food-restricted animals and those with chronically elevated concentrations of the liver hormone. Kliewer’s team further showed that the hormone contributes to energy-conserving behavioral changes as animals ride out food shortages.

 

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Categorie: lowcarb

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