Doubts over studies raise serious implications for patients

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Omschrijving
Doubts over three influential head injury studies mean that patients are receiving treatment that may be unsound, warn doctors in this week's BMJ.

Professor Ian Roberts and colleagues describe the worrying story of Dr Julio Cruz, a neurosurgeon who published three trials on the use of the drug mannitol for head injuries between 2001 and 2004. The results showed that high dose mannitol greatly reduced death and disability six months after the head injury, but they have recently been called into question.

Dr Cruz committed suicide two years ago and his co-authors and the editors of the journals in which the three papers were published have failed to respond adequately to the concerns raised about the integrity of the data.

Despite considerable efforts, Professor Roberts and his colleagues say they are left with serious doubt about important studies but with no way of determining with confidence whether the results are fabricated or real. [Ben Licher]

 

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