Genetic Inability To Detoxify Cigarette Smoke Increases Cleft Lip Risk

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Omschrijving
A fetus that lacks both copies of a gene involved in detoxifying cigarette smoke and whose mother smokes during the pregnancy has a substantially increased risk of developing a cleft lip and/or palate, according a University of Iowa-led international study.

About 25 percent of babies of European ancestry and up to 60 percent of those of Asian ancestry lack both copies of the gene, which is called GSTT1. The finding is believed to mark the first time a gene-environment interaction in clefting has been documented at the molecular level. The study, which appears in the January issue of the American Journal of Human Genetics, was funded by the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health.

"If a pregnant woman smokes 15 cigarettes or more per day, and her fetus doesn't have any working copies of the GSTT1 gene, then the chances of the fetus developing a cleft increase nearly 20 fold," said Jeff Murray, M.D., the study's senior author and professor of pediatrics in the UI Roy J. and Lucille A. Carver College of Medicine with joint appointments in pediatric dentistry in the College of Dentistry, biology in the College of Liberal Arts and Sciences, and epidemiology in the College of Public Health.

 

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Categorie: roken - baby

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