Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases

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Omschrijving
The anti-inflammatory properties of 3 fatty acids, especially EPA, are due to competition with arachidonic acid (AA) as a substrate for cyclooxygenases and 5-lipoxygenase. The eicosanoids from the 6 and 3 fatty acids have opposing properties. The eicosanoids are considered a link between PUFA, inflammation and immunity. In addition to their effects on prostaglandins, thromboxanes and leukotrienes, 3 fatty acids suppress the production on interleukin 1 (IL-1ß) by suppressing the IL-1ß mRNA, as well as the expression of Cox2 (cytooxygenase) mRNA that is induced by IL-1ß. Cox2 is overexpressed in colon cancer cells. Both ALA, and EPA and DHA are involved in immune function. The precise effect of ALA depends on the level of linoleic acid (LA) and total PUFA content of the diet.

 

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Categorie: omega 3 - ontstekingen

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