Researchers at Illinois explore queen bee longevity
Omschrijving
The researchers knew from studies of the fruit fly and nematode that the insulin-signaling pathway had a role in longevity. Down-regulation of insulin-IGF-1 signaling (IIS) in those species was associated with increases in longevity – but at the expense of fertility. They also knew that manipulating fat body cells in the head of the fruit fly influenced longevity. Because Vg is synthesized in fat body cells in honey bees, the team decided to look at Vg expression in the head and thorax as well as the abdomen.
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Categorie: igf - aging
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