Molecular Mechanisms of the Diabetogenic Effects of Arsenic - Inhibition of Insulin Signaling by Arsenite and Methylarsonous Acid
Omschrijving
Increased prevalences of diabetes mellitus have been reported among individuals chronically exposed to inorganic arsenic (iAs) . However, the mechanisms underlying the diabetogenic effects of iAs have not been characterized. We have previously shown that trivalent metabolites of iAs, arsenite (iAsIII) and methylarsonous acid (MAsIII) inhibit insulin-stimulated glucose uptake (ISGU) in 3T3-L1 adipocytes by suppressing the insulin-dependent phosphorylation of protein kinase B (PKB/Akt) .
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Categorie: diabetes - arsenicum
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