UI team identifies genes that improve survival in mice with ALS

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Omschrijving
University of Iowa researchers investigating the basic biology of cell signaling have made a discovery that may have therapeutic implications for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The UI team, led by John Engelhardt, Ph.D., professor and head of anatomy and cell biology in the UI Roy J. and Lucille A. Carver College of Medicine, discovered that two cell-signaling proteins called Nox1 and Nox2 appear to play an important role in disease progression of an inherited form of ALS. This work is published in the Sept. 13 issue of the Journal of Clinical Investigation.Deleting either Nox1 or Nox2 genes from mice with the inherited type of ALS significantly increased the lifespan of the mice. Nox2 deletion produces the most dramatic effect, nearly doubling the lifespan of the mice. In addition, Nox2 deletion dramatically increased the survival index -- the time from disease onset to death. This is the first report of a single gene that affects the survival index in ALS models.

 

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Categorie: als

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