Broccoli and the Blood Brain Barrier

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Omschrijving
As if there weren't enough reasons to eat your vegetables, this week Zhao et al. report that a substance in broccoli helps to maintain the integrity of the blood-brain barrier (BBB) following a cortical contusion injury. Systemic administration of sulforaphane, contained in broccoli and other cruciferous vegetables, increased activity of NF-E2-related factor-2 (Nrf2). Nrf2 binds to the antioxidant response element (ARE), influencing expression of so-called cytoprotective proteins. Sulforaphane treatment of uninjured and brain-injured rats increased cortical expression of Nrf2-driven genes. Infusion of NR decoy oligonucleotides containing the ARE binding site for Nrf2 prevented sulforaphane-induced, Nrf2-driven gene expression. Tight junction proteins are key to maintaining BBB integrity, and they decline after brain injury. Sulforaphane attenuated the loss of these proteins as well as the loss of endothelial cells and also reduced the injury-related increase in BBB permeability and brain edema. OK, OK, pass the broccoli.

 

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Categorie: broccoli - hersenen

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