Nitrosothiols signal hypoxia-mimetic vascular pathology

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Omschrijving
In summary, these data (a) provide the first in vivo measurements to our knowledge suggesting that NO can signal erythrocytic oxygen desaturation through S-nitrosothiol formation; (b) introduce a novel murine model of PAH, one in which transgenic animals are informative; (c) provide one explanation for previously reported, hypoxia-mimetic effects of NAC; and (d) suggest that PAH may be an unappreciated risk of systemic therapy with the pharmaceutical antiinflammatory and antioxidant agent NAC.

 

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